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Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
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在短肠综合征的教科书结局
Jon S Thompson1, Fedja A Rochling2, Elizabeth Lyden3
1Department of Surgery, University of Nebraska Medical Center Omaha, Nebraska, USA.
American journal of surgery
|September 21, 2024
概括
教科书结局 (TO) 在15%的短肠综合征 (SBS) 患者中实现. 肠残留物长度和解剖学独立地预测TO,突出了理想SBS护理的关键因素.
科学领域:
- 胃肠病学和肝病学
- 手术结果研究研究.
- 患者护理质量 患者护理质量
背景情况:
- 教科书结局 (TO) 代表了医疗条件的理想护理标准.
- 短肠综合征 (SBS) 患者面临严重的并发症和死亡风险.
- 确定SBS中TO发生率和预测因素对于改善患者管理至关重要.
研究的目的:
- 确定短肠综合征 (SBS) 的成年患者中教科书结局 (TO) 的发生率.
- 确定预测SBS患者TO成就的人口统计学,解剖学和营养因素.
主要方法:
- 在退院后12个月内,对515名成人SBS患者进行了随访.
- 用八个特定的结果参数来定义TO.
- 分析了患者的人口统计,肠道解剖学和营养状况,以确定与TO的关联.
主要成果:
- 15%的SBS患者实现了TO.
- 关键的组成部分包括TO亲肠营养 (PN) <1年 (39%),BMI>18.5公斤/平方米 (89%),没有口腔 (59%),没有再入院 (56%),和生存率 (97%).
- 肠道残留物长度和解剖学类型成为实现TO的重要预测因素.
结论:
- 15%的SBS患者根据定义的标准实现了教科书结果 (TO).
- 对TO的主要障碍是持续需要亲肠道营养 (PN).
- 肠道长度和解剖学特征被确定为影响SBS中TO达到的独立预测因素.
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