抗真菌易感性测试:在资源有限的环境中改善访问的方法和策略的适用性
Richard Kwizera1, Alireza Abdolrasouli2, Guillermo Garcia-Effron3
1Department of Research, Infectious Diseases Institute and Department of Medical Microbiology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.
The Lancet. Infectious diseases
|September 21, 2024
概括
菌中的抗真菌耐药性增加了死亡风险. 在资源有限的地区实施抗真菌敏感性测试 (AFST) 是可行的,对于指导治疗和改善患者结果至关重要.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
背景情况:
- 人类真菌病原体的抗真菌耐药性正在上升,导致治疗失败和死亡率增加.
- 准确和快速识别真菌物种对于预测内在抗真菌耐药性至关重要.
- 抗真菌敏感性测试 (AFST) 尽管具有临床重要性,但在资源有限的环境中基本上无法使用.
研究的目的:
- 探索在资源有限的环境中实施抗真菌敏感性测试 (AFST) 的可行性.
- 为解决全球范围内关于AFST服务可访问性的更广泛问题.
- 概述一个实用的框架,以在服务不足的地区建立可持续的AFST.
主要方法:
- 审查现有的AFST方法,适用于资源有限的环境 (例如,亚加扩散,渐变扩散).
- 关于AFST的七步实施计划的建议,优先考虑准确的物种识别.
- 专注于关键的真菌病原体:白 Candida,白 Candida parapsilosis,白 Candida glabrata,以及化 Aspergillus.
主要成果:
- 通过结构化方法,AFST的实施在资源有限的环境中是可行的.
- 可持续的AFST服务的关键要求包括资金,培训,协议,试剂,质量控制和外部质量保证.
- 准确的物种鉴定是预测抗真菌耐药性的关键第一步.
结论:
- 可持续的AFST服务对于指导患者护理,生成监测数据和加强抗真菌管理至关重要.
- 政治承诺和国际合作对于加强全球AFST服务提供至关重要.
- 扩大AFST可访问性对于打击真菌感染中抗真菌耐药性日益增长的威胁至关重要.
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