在中年和老年人中,多种金属暴露与认知功能之间的关联:来自中国的横截面研究
Shiru Hong1, Sheng Wu2, Zhengce Wan3
1Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Environmental research
|September 21, 2024
概括
暴露于金属会影响老年人的认知能力下降. 虽然铁和具有保护作用,但和暴露与认知功能下降有关,而可能会减轻这些风险.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 认知能力下降对老龄化人口构成重大挑战.
- 环境金属暴露对认知功能的影响越来越令人担忧,但研究结果仍然不确定.
- 了解多种金属暴露的复杂相互作用对于公共健康至关重要.
研究的目的:
- 研究多种金属的血水平与中老年人和老年人的认知功能之间的关联.
- 探索特定金属对认知表现的个体,互动和综合作用.
主要方法:
- 在6112名参与者中,使用诱导合等离子体质谱学分析了23种金属的等离子体金属含量.
- 使用迷你精神状态检查 (MMSE) 评估认知功能.
- 统计分析以确定金属含量和MMSE分数之间的关联和相互作用.
主要成果:
- 血铁 (Fe) 和 (Zn) 含量升高与MMSE得分更高有积极的相关性.
- 血 (Ni) 和 (Pb) 水平的增加与MMSE得分的降低有关.
- 和Pb对认知表现出协同作用的毒性作用,特别是在低水平的个体中,这表明的保护作用.
结论:
- 血Fe和Zn与更好的认知功能有关,而Ni和Pb与认知衰退有关.
- 可能会减轻和暴露的不良认知影响.
- 对这些金属的累积暴露显著影响认知功能,凸显了进一步研究和潜在干预措施的必要性.
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