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Updated: Jun 12, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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Published on: August 21, 2021

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阿尔法同核素以DNA-PKcs调节的方式调节基因组DNA双链断裂的修复

Elizabeth P Rose1, Valerie R Osterberg2, Vera Gorbunova3

  • 1Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR 97239, United States of America; Neuroscience Graduate Program, Vollum Institute, Oregon Health & Science University, Portland, OR 97239, United States of America.

Neurobiology of disease
|September 21, 2024
PubMed
概括

阿尔法同核素 (αSyn) 蛋白质损失通过NHEJ通路损害了DNA双链断裂修复. 这表明αSyn在维持帕金森氏症等神经退行性疾病中的基因组稳定性方面发挥了作用.

关键词:
DNA双链断裂修复的修复方法DNA-PK ((cs) 的意思是什么?莱维体病是莱维体病的一种疾病.帕金森病是帕金森病的一种.α-Synuclein 是一种蛋白质.

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