相关实验视频
Updated: Jun 12, 2025

09:33
Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules
Published on: May 12, 2017
14.6K
压力颗粒在六价诱导的恶性瘤中发挥着关键作用,以一种依赖G3BP1的方式
Brian Shaw1, Phyo Han Thwin2, Nan Jia2
1Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA; Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA.
Environmental pollution (Barking, Essex : 1987)
|September 21, 2024
概括
六价 (Cr(VI)) 暴露会触发压力颗粒的形成,从而促进癌症的发展. 针对这些依赖G3BP1的压力颗粒,提供了针对CrVI诱导恶性瘤的新策略.
科学领域:
- 细胞生物学 细胞生物学
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 压力颗粒 (SG) 是动态的细胞结构,参与细胞存活,增殖和恶性瘤.
- 六价 (Cr(VI)) 是一种有毒金属,与环境健康风险和癌症有关.
- 在Cr (VI) 诱导的细胞损伤和癌症中SGs的具体作用尚不清楚.
研究的目的:
- 调查Cr(VI) 暴露对SG动态的影响.
- 确定SGs在Cr (VI) 诱导的恶性瘤中的作用.
- 探索Cr (VI) 毒性的潜在治疗点.
主要方法:
- 人类支气管上皮细胞 (BEAS-2B) 暴露于不同度和时间的CrVI.
- 对SG形成和细胞恶性性质的分析.
- 在Cr(VI) 转化细胞中对SG核心蛋白G3BP1进行基因操纵 (Knockout).
主要成果:
- 无论是急性高剂量还是慢性低剂量Cr (VI) 暴露都诱导了SG的形成.
- 预先暴露于Cr6增强了SG反应.
- 在长期暴露于低剂量Cr的细胞中,增加SG形成与增强的恶性性质相关.
- 在Cr(VI) 转化细胞中,G3BP1淘汰会减少SG形成和恶性特征.
结论:
- 压力颗粒在调解Cr (VI) 诱导的恶性瘤方面发挥着至关重要的作用.
- 这种效果取决于SG核心蛋白G3BP1.1.
- SGs代表了一种新的机制和潜在的治疗点,用于Cr (VI) 毒性.
相关概念视频
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
DNA Damage can Stall the Cell Cycle
9.1K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.1K
Mutagenicity and Carcinogenicity
1.2K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.2K
Negative Regulator Molecules
35.2K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.2K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K

