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在九个欧洲国家的症状性莱姆病病发病率

Frederick J Angulo¹, Emily Colby¹, Anne-Mette Lebech²

¹Vaccines and Antivirals Medical Affairs, Pfizer US Commercial Division, Collegeville, PA, USA.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

|September 21, 2024

概括

这项研究通过调整监测数据以进行不足检测,揭示了整个欧洲症状性莱姆病 (LB) 的高发病率. 了解这些Borrelia burgdorferi sensu lato (Bbsl) 感染率对于公共卫生至关重要.

科学领域:

传染性疾病传染性疾病
流行病学流行病学
公共卫生监督公共卫生监督

背景情况:

莱姆病 (Lyme borreliosis,简称LB) 是欧洲的一个重大公共卫生问题.
目前的监测数据可能低估了症状性Borrelia burgdorferi sensu lato (Bbsl) 感染的真实负担,原因是检测不足.

研究的目的:

估计9个欧洲国家的症状性BBSL感染的发病率.
为了调整现有的LB监测数据,以低于症状病例的检测.

主要方法:

利用了来自血清流行研究和文献评论的关于症状比例和抗体检测持续时间的数据.
应用不足检测乘数到公共卫生LB监测数据.
2018年至2022年9个欧洲国家的估计发病率.

主要成果:

反Bbsl抗体的患病率从2.3% (罗马尼亚) 到9.4% (德国) 不同.
低检测乘数根据监控系统类型 (例如,所有LB病例与仅莱姆神经病变) 有显著差异.
在芬兰,德国,挪威,波兰和瑞士观察到症状性Bbsl感染的最高调整发病率.

结论:

调整LB监测数据显示,在多个欧洲国家,症状性BBSL感染的发病率很高.
在比较数据和估计疾病负担时,国家LB监测系统的变化需要仔细考虑.

关键词:

疾病负担疾病负担流行病学流行病学莱姆病是莱姆病的一种疾病.血清的流行程度是如此.监督监督监督监督监督监督传播的疾病.

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