达卡伊胡开通过调节MAPK信号通路来缓解慢性胰腺炎:来自网络药理学和实验验证的见解
Xu Li1, Zhangli Yan1, Xin Cao1
1Basic Medical Academy, Shaanxi University of Chinese Medicine, Xianyang, China.
Journal of ethnopharmacology
|September 21, 2024
概括
达开 (Dachaihu Decoction,简称DCHD) 通过减少胰腺炎和纤维化,有效治疗慢性胰腺炎 (CP). 它的机制涉及调节基因激活蛋白激酶 (MAPK) 信号通路,为CP提供了一个有前途的治疗方法.
科学领域:
- 综合医学将传统中医与现代药理学方法相结合.
- 胃肠病学和肝病学,专注于胰腺疾病.
- 药理学和分子生物学,研究治疗机制.
背景情况:
- 慢性胰腺炎 (CP) 是一种进展性炎症性疾病,损害胰腺功能,全球发病率不断增加,病因不明.
- 传统中国医学将CP归因于绍阳和明综合征;达开 (DCHD) 用于这些情况.
- DCHD在预防和治疗CP的确切机制尚不清楚.
研究的目的:
- 为了探索大开 (DCHD) 在慢性胰腺炎 (CP) 中的潜在治疗机制.
- 利用整体方法,整合网络药理学,分子对接,转录学和动物实验.
- 在CP小鼠模型中验证DCHD的疗效和潜在途径.
主要方法:
- 在小鼠中诱导CP使用caerulein和通过胃洗给药DCHD.
- 采用网络药理学和分子对接来识别DCHD活性成分,标和途径.
- 进行了胰腺组织的转录基因分析,并进行了体内/体外实验以验证.
主要成果:
- 在CP小鼠中,DCHD改善了胰腺损伤,炎症和纤维化.
- 网络药理学确定了385个CP的DCHD目标;KEGG分析将DCHD的影响与MAPK信号通路联系起来.
- DCHD抑制了MAPK信号传递,减少了胰腺组织,星状细胞和巨细胞中P38,JNK和ERK的酸化;贝卡林显示出类似的效果.
结论:
- 达开 (Dachaihu Decoction,简称DCHD) 在慢性胰腺炎 (CP) 中显示出显著的治疗潜力.
- 在CP中,DCHD的抗炎和抗纤维作用很可能通过调节MAPK信号通路来调节.
- DCHD可能代表一个有前途的治疗药物来管理CP进展.
相关概念视频
01:24Chronic Pancreatitis I: Introduction
76
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
76
01:29Chronic Pancreatitis II: Collaborative Care
70
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
70
01:30Acute Pancreatitis II: Clinical Manifestations and Management
95
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
95
01:27Acute Pancreatitis I: Introduction
339
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
339