年龄相关疾病的老年人便肠道透性和肠道炎症标志物:系统性审查和元分析
Nurul Izzati Ahmad Fadzuli1, Siong Meng Lim1, Chin Fen Neoh1
1Collaborative Drug Discovery Research (CDDR) Group, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Cawangan Selangor, Kampus Puncak Alam, Bandar Puncak Alam, Selangor Darul Ehsan 42300, Malaysia.
这项研究发现,在患有帕金森病和其他神经疾病的老年人中,便中的α-1-抗素和calprotectin水平较高. 便calprotectin显示出作为肠道炎症标记物的承诺.
科学领域:
- 胃肠病学和神经病学
- 在衰老和神经退行性疾病中发现生物标志物
背景情况:
- 肠道透性和炎症与衰老和神经退行性疾病 (如帕金森病和阿尔茨海默病) 有关.
- 具体的便标志物需要进一步调查,以确认它们在老年人中的有用性.
研究的目的:
- 系统地审查和分析现有的关于老年人便肠道透性和炎症标志物的文献.
- 在PD和AD等疾病中识别肠道功能障碍的潜在生物标志物.
主要方法:
- 系统的文献搜索确定了十项符合条件的研究.
- 便标记物的元分析,包括α-1-抗素,佐努林,calprotectin,乳酸铁素和NGAL.
- 在患有PD,AD,MSA的老年人中,与健康对照对标水平的比较.
主要成果:
- 与非PD个体相比,患有PD的老年人便α-1-抗素显著增加 (p < 0.00001).
- 在患有胃肠道症状,MSA或PD的老年人中,便calprotectin的升高与健康对照组相比 (p = 0.05).
- 在PD和非PD个体之间,便中素没有显著差异,具有很高的异质性.
结论:
- 便中的calprotectin成为老年人患有特定神经疾病的肠道炎症的潜在标志物.
- 关于便α-1-抗素作为肠道透性标记物的发现需要进一步验证.
- 需要更多的研究来证实这些便标志物在衰老和神经退行症中的作用.
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