长期心率升高与严重肺栓塞的不良结果有关:一项回顾性研究
Guangdong Wang1, Tingting Liu1, Wenwen Ji1
1Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi 710061, China.
International journal of cardiology
|September 21, 2024
概括
长期心率升高 (peHR) 在严重肺栓塞 (PE) 患者中显著增加死亡率. 密切的心率监测和管理对于改善这些关键病例的生存结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 关键护理医学 关键护理医学
- 肺部医学 肺部医学
背景情况:
- 肺栓塞 (PE) 是一种危及生命的疾病,导致全球显著的发病率和死亡率.
- 长期心率升高 (peHR) 是重症监护中的已知危险因素,但其对严重PE的具体影响以前没有被研究.
研究的目的:
- 调查长期心率升高 (peHR) 与严重肺栓塞 (PE) 患者的死亡率之间的关联.
主要方法:
- 一项使用MIMIC-IV数据库的回顾性队列研究.
- 定义的peHR是心率>100bpm在12小时内至少11次.
- 采用Cox比例危险回归来评估peHR对30天和90天死亡率的影响,并对共变量进行调整.
主要成果:
- 这项研究包括1248名PE患者,其中540人表现出peHR.
- 患有peHR的患者在医院和ICU停留时间更长,30天 (25.93%vs14.97%) 和90天 (33.89%vs22.74%) 的死亡率明显更高.
- 多变量分析确定了peHR作为30天 (HR 1.56) 和90天 (HR 1.66) 死亡率增加的独立预测因素.
结论:
- 长时间心率升高 (peHR) 与严重肺栓塞 (PE) 患者的结果明显恶化有关.
- 强调严格的心率监测和严重PE的管理的重要性.
- 建议将心率控制纳入临床管理策略,以潜在地提高PE患者的存活率.
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