通过单碳新陈代谢,将碳带到生命中
Samantha O'Keeffe1, Lilly Garcia1, Yi Chen2
1Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Trends in biotechnology
|September 21, 2024
概括
本综述探讨了用于将未充分利用的单碳 (C1) 化合物转化为有价值产品的代谢策略. 通过共同养和能量转导来提高能源的可用性,可以克服C1利用和碳上循环的局限性.
科学领域:
- 生物技术是生物技术.
- 代谢工程是代谢工程.
- 可持续化学 可持续化学
背景情况:
- 在温室气体和工业废物中普遍存在的一碳 (C1) 化合物,代表未开发的碳和能源资源.
- 目前用于将C1基板转化为多碳产品的方法在实现净经济价值方面面临挑战.
- 生物化学C1利用通常受到高能量需求的限制,特别是细胞过程和热力学不利反应所需的腺三酸盐 (ATP).
研究的目的:
- 审查和分析代谢策略,以便在各种氧化状态中有效利用碳.
- 探索C1转化过程中克服能源限制和代谢瓶的方法.
- 提供关于C1化合物价值化的生物能源,工程和技术经济方面的全面观点.
主要方法:
- 对C1化合物同化代谢途径的现有文献的审查.
- 对控制C1利用和ATP生产的生物能源原理的分析.
- 检查工程策略,包括基质共和外部能量转导 (光,电),以提高代谢效率.
- 对C1转换技术的技术经济评估.
主要成果:
- 代谢策略可以有效地利用C1化合物中存在的不同氧化状态中的碳.
- 通过基质共和能量转导来改善腺三酸盐 (ATP) 的可用性,可以缓解代谢瓶.
- 这些方法提高了碳上循环,将废物流转化为有价值的多碳产品.
- 生物能源,工程和技术经济考虑的整合对于成功的C1价值化至关重要.
结论:
- 代谢工程为C1化合物的可持续价值化提供了有希望的途径.
- 克服能源限制是释放这些未充分利用资源潜力的关键.
- 综合生物能源学,工程学和经济学的多学科方法对于开发可行的C1转换技术至关重要.
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