口腔癌患者的酸盐水平变化 - 认识到再养综合征的风险
Suvi Silén1, Erika Wilkman2, Emilia Haukilehto3
1Department of Otorhinolaryngology, Head and Neck Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. suvi.silen@helsinki.fi.
概括
老年口腔癌患者有较高的风险重新养综合征 (RFS) 由于外科手术期间的低度血. 密切监测老年患者的酸盐水平对于预防这种可能致命的疾病至关重要.
科学领域:
- 在瘤学瘤学.
- 手术重建手术重建的方法
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 口腔状细胞癌 (OSCC) 患者在住院期间面临营养挑战和再养综合征 (RFS) 风险.
- 重新养综合征可能是致命的,如果不及时管理.
- 在OSCC患者中确定RFS的诱导因素对于有效的管理至关重要.
研究的目的:
- 为了研究OSCC患者的外科手术期间酸盐水平的变化.
- 在OSCC患者中确定RFS症状的发生.
- 确定导致OSCC患者患RFS的临床因素.
主要方法:
- 对初级OSCC患者进行微血管自由重建的回顾性分析.
- 排除患有其他恶性瘤,甲状腺功能低下症或缺少酸盐数据的患者.
- 结果变量:严重的术后低酸血症 (P-Pi <0.50 mmol/l);预测变量包括人口统计,并发病,瘤特征和营养支持.
主要成果:
- 在189名OSCC患者中,21%患有严重的低酸血,其中81%患有RFS症状.
- 较高的年龄,较低的患者身高和非吸烟者身份与术后低酸血症有显著的关联.
- 多变量分析证实年龄较大 (每年和70岁以上) 是严重低酸血症的独立风险因素.
结论:
- 术后营养和电解质平衡管理对于预防OSCC患者的RFS至关重要,特别是那些经历了广泛的重建的患者.
- 老年患者需要特别注意,因为他们对RFS的敏感性增加.
- 早期识别和治疗低酸盐血症可以预防这种人群中可能危及生命的RFS.
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