代谢综合征中的便和血液代谢学:一个横截面研究
Mariana Ponce-de-Leon1,2, Rui Wang-Sattler3,4, Annette Peters5,4,6,7
1Institute for Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany. mariana.ponce-de-leon@outlook.com.
Metabolomics : Official journal of the Metabolomic Society
|September 21, 2024
概括
代谢综合征 (MetS) 与许多肠道和血液代谢物有关,其中一些与炎症有关. 然而,肠道和血液代谢物相关性仍然很弱,这表明不同的代谢途径.
科学领域:
- 代谢学 代谢学 代谢学
- 系统生物学 系统生物学
- 人类健康 人类健康 人类健康
背景情况:
- 代谢综合征 (MetS) 是一组增加心脏病,中风和2型糖尿病风险的疾病.
- 便代谢组在MetS中的作用还未得到充分研究,其与循环代谢产物之间的关系也是如此.
研究的目的:
- 调查便和血液代谢物,MetS和全身炎症之间的关联.
- 为了探索肠道和循环代谢物之间的关系,在个人 MetS.
主要方法:
- 对来自KORA FF4研究的1370名参与者的分析.
- 不针对性便和针对性血液代谢物分析.
- 多重线性回归和多态因子分析 (MOFA) 来评估关联和关系.
主要成果:
- MetS与170种便和82种血液代谢产物有关.
- 甘油三和高血糖水平显示出与分别便和血液代谢产品的关联最多.
- 便和血液中的许多MetS相关代谢物与hsCRP水平相关,表明炎症联系.
结论:
- MetS和脂质失调与不同的便和血液代谢物有关,其中一些与全身炎症有关.
- 在便和血液代谢物之间观察到微弱的相关性,表明有限的重叠.
- 需要使用综合方法进行进一步的研究,以了解这些代谢变化.
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