叶酸和前列腺癌风险之间的因果关系:从孟德尔随机化分析的见解
Xiaoxiao Guo1,2, Fengbo Zhang1,2, Gangyue Hao1,2
1Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
概括
叶酸补充剂可能会增加前列腺癌 (PCa) 风险,而食叶酸相当剂则不会. 这项门德尔随机化研究强调了PCa预防策略对公共卫生的潜在影响.
科学领域:
- 遗传学和流行病学
- 营养科学 营养科学
- 在瘤学瘤学.
背景情况:
- 叶酸是一种常见的食补充剂.
- 人们担心叶酸补充剂与前列腺癌 (PCa) 风险增加之间存在潜在联系.
- 饮食中叶酸摄入量与PCa风险之间的关系需要进一步研究.
研究的目的:
- 调查PCa和叶酸补充剂之间的潜在因果关系.
- 检查饮食中的叶酸相当剂与PCa风险之间的关联.
- 使用孟德尔随机化 (MR) 分析来进行强大的因果推断.
主要方法:
- 全基因组关联研究 (GWAS) 的叶酸补充剂和食叶酸等效的数据来源于英国生物银行.
- 对PCa的GWAS元分析数据来自PCa协会小组,以调查基因组联盟中的癌症相关变化.
- 使用逆方差加权 (IVW) 和其他方法进行了门德尔随机化分析,并进行了异质性,类型和反向因果测试.
主要成果:
- 六个单核酸多态 (SNP) 用于叶酸补充剂和五个SNP用于食叶酸等价物被确定为仪器变量.
- 基因预测的叶酸补充与PCa风险增加显著相关 (OR 1.200,p < 0.001).
- 在所有MR方法中,食中的叶酸相当剂与PCa风险没有显著的相关性.
结论:
- 叶酸补充与前列腺癌的风险增加有关.
- 饮食中的叶酸相当剂似乎没有影响前列腺癌风险.
- 研究结果支持针对性公共卫生干预和针对PCa的个性化预防.
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