过敏性鼻炎缓解与室内灰尘子皮下免疫疗法
Supamas Harintajinda1, Natchanun Klangkalya1, Watcharoot Kanchongkittiphon1
1Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Asian Pacific journal of allergy and immunology
|September 22, 2024
概括
家庭灰尘子皮下免疫疗法 (HDM SCIT) 为过敏性鼻炎 (AR) 提供了持久的缓解. 在15岁之前的早期治疗和缺少喘预测在停止HDM SCIT后成功的长期缓解.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 临床医学 临床医学
- 免疫疗法研究 免疫疗法研究
背景情况:
- 室内灰尘子皮下免疫疗法 (HDM SCIT) 是过敏性鼻炎 (AR) 患者具有耐火症状的选择.
- 标准药物往往不足以控制某些患者群体的AR症状.
研究的目的:
- 为了评估停用后的HDM SCIT的长期有效性.
- 为了确定预测AR患者在HDM SCIT后临床缓解的因素.
主要方法:
- 一组240名AR患者完成了3年的HDM SCIT,在停止治疗后进行了跟踪.
- 临床缓解被定义为每天不使用鼻内类固醇或口服抗胰岛素.
- 用多变量逻辑回归分析了缓解的预测因素.
主要成果:
- 72.5%的患者实现了AR的临床缓解.
- 在15岁之前启动HDM SCIT (aOR4.44) 和没有喘 (aOR2.67) 是缓解的显著预测因素.
- 在转移性和非转移性组之间没有观察到治疗持续时间或敏感化模式的显著差异.
结论:
- 在HDM SCIT中,即使在治疗停止后,也显示了持续的长期疗效.
- 早期启动HDM SCIT (15岁之前) 和缺少喘可能预测成功的AR缓解.
相关概念视频
Allergic Reactions
27.3K
Overview
27.3K
Asthma: Pathogenesis and Management
364
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
364
Hypersensitivities
550
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
550
Drugs Used in Lower Respiratory Disorders: Overview
360
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
360
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K


