美国抗发作药物的定价动态
Pradeep Javarayee1, Tengizi Mtchedlidze2, Wanda Snell1
1Division of Child Neurology, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, United States.
Seizure
|September 22, 2024
概括
品牌抗发作药物 (ASM) 的成本大幅增加,而仿制药的成本下降,扩大了价格差距. 更通用的竞争矛盾地提高了品牌ASM价格,影响了治疗成本.
科学领域:
- 药物经济学 药物经济学
- 药品定价动态 药品定价动态
- 卫生政策 卫生政策
背景情况:
- 在美国,抗发作药物 (ASM) 的中位成本在2006年至2021年之间几乎翻了一番.
- ASM使用的转变,供应链中断 (COVID-19) 和通货膨胀需要对ASM定价进行分析.
- 由于成本上升,迫切需要仔细审查ASM定价动态.
研究的目的:
- 分析2013-2023年美国抗药物定价动态.
- 调查通用ASM条目对品牌对手价格的影响.
- 确定影响不同ASM配方价格波动的因素,包括通货膨胀和COVID-19大流行.
主要方法:
- 使用的全国平均药物采购成本 (NADAC) 数据 (2013年11月 - 2023年7月).
- 用药品消费者价格指数 (CPI-MDS) 调整了通货膨胀的ASM价格.
- 采用固定效应和多变量回归分析来评估通胀,标签计数和COVID-19对价格的影响.
主要成果:
- 品牌ASM价格从8.71美元上到15.43美元,而仿制药价格则从1.39美元略有下降到1.26.6美元.
- 品牌和通用ASM之间的价格差距从1452.39%升至3399.26%.
- 增加的仿制品标签者降低了仿制品价格,但矛盾的是增加了品牌价格;COVID-19增加了品牌价格,降低了仿制品ASM价格.
结论:
- 品牌和通用口服ASM之间存在着日益扩大的价格差异.
- 药物标签的数量反向影响通用ASM价格,但增加品牌ASM价格.
- 调查结果突出了"仿制药悖论",并要求针对药物定价的干预措施,以获得公平的治疗.
关键词:
抗发作药物 抗发作药物品牌药物的价格 品牌药物的价格在COVID-19大流行中,药品定价是药品的定价.是一种病.仿制药的价格 仿制药的价格通货膨胀 这就是通货膨胀.药品价格 药品价格 药品价格专利到期的时间 专利到期的时间更多相关视频
06:45Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
Published on: January 19, 2019
8.9K
06:28Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems
Published on: September 27, 2024
2.2K
相关概念视频
01:20Antiepileptic Drugs: Potassium Channel Activators
149
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
149
01:20Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
266
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
266
01:08Antiepileptic Drugs: Sodium Channel Blockers
452
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
452
01:18Antiepileptic Drugs: GABAergic Pathway Potentiators
341
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
341
01:14Antiepileptic Drugs: Glutamate Antagonists
292
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
292
01:17Antiepileptic Drugs: Calcium Channel Blockers
341
Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
341