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暴露于有机酸代谢物和肉病的流行率之间的关联:使用NHANES数据的横截面研究
Wenbin Nan1, Zhenyu Peng1, Ting Yi2
1Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, NO. 139 Middle Renmin Road, Changsha 410011, China.
Ecotoxicology and environmental safety
|September 22, 2024
概括
有机酸 (OPEs) 暴露与肉症有关,这是一种肌肉衰弱的疾病. 尿中代谢物丁酸盐 (DBUP) 和bis (2-chloroethyl) 酸盐 (BCEP) 与肉症风险呈正相关性.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 老年学是一门学科.
背景情况:
- 有机酸盐 (OPEs) 是一种普遍存在的环境污染物,具有已知的健康风险.
- 对OPEs暴露对标症的影响,标志着肌肉损失和软弱,尚不清楚.
- 了解环境毒素对与年龄相关的肌肉衰减的影响至关重要.
研究的目的:
- 为了调查尿液OPE代谢物和肉病患的患病率之间的关联.
- 为了确定与增加的肉症风险相关的特定OPE代谢物.
- 探索炎症在调解这种关系中的作用.
主要方法:
- 利用了2011-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 分析了OPE的尿中代谢物和诊断的肉症.
- 采用加权量子式总和 (WQS) 回归和中介分析.
主要成果:
- 在尿路二丁酸盐 (DBUP) 和bis (2-chloroethyl) 酸盐 (BCEP) 和肉症风险之间发现了积极的相关性.
- 通过WQS分析,DBUP显示了对萨尔科佩尼亚发展的最显著贡献.
- 炎症被确定为DBUP/BCEP暴露和肉症之间的关系的调解者.
结论:
- 由尿中代谢物DBUP和BCEP表示的OPE暴露与缩症的风险增加有关.
- 炎症在OPE诱导的肉症中起着调解作用.
- 需要进一步的前性研究来证实这些发现,并探索OPE对肌肉健康的影响.
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