百合素通过激活肝脑纤维细胞生长因子-21信号来缓解与年龄相关的认知缺陷
1Nutritional and Food Sciences Research Institute, Department of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China; MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China.
Redox biology
|September 22, 2024
概括
烯 (LYC) 治疗通过激活肝脑纤维细胞生长因子21 (FGF21) 信号来改善与年龄相关的记忆丧失. 这增强了神经元功能和线粒体能量生产,这表明FGF21是认知衰退的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 代谢过程中的代谢.
- 营养科学 营养科学
背景情况:
- 大脑功能与肝脏等外围器官密切相关,肝脏纤维细胞生长因子21 (FGF21) 介导肝脏与大脑的通信.
- 利科 (LYC) 是一种强有力的抗氧化类胡卜素,具有与年龄相关的认知衰退相关的神经保护性质.
研究的目的:
- 研究LYC对与年龄相关的记忆障碍的影响.
- 确定肝脑FGF21信号传输在LYC神经保护作用中的作用.
主要方法:
- 给老年小鼠3个月的LYC.
- 使用腺相关病毒 (AAV) 注射抑制FGF21信号传递.
- 在实验室研究中使用小鼠海马HT-22细胞.
- 在Transwell系统中共培养肝细胞和神经元.
主要成果:
- 在老年小鼠中,LYC治疗改善了认知缺陷,改善了神经元退化,线粒体功能障碍和突触损伤.
- LYC激活了肝脑FGF21信号传输,这对其核心作用至关重要.
- 在体外,FGF21增强了线粒体ATP生产和突触囊泡融合,促进了神经递质释放.
- 用LYC治疗的肝细胞在共同培养中改善了神经元衰老,线粒体功能和轴突长度.
结论:
- 通过激活肝脑FGF21信号传递,LYC可以防止与年龄相关的认知缺陷.
- 这种激活通过增加线粒体ATP和增强突触囊泡融合促进神经递质释放.
- FGF21代表了与年龄相关的认知损伤和神经退行性疾病的营养干预的潜在治疗目标.
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