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表面电荷可切换的化小分子微粒用于增强的光动力学治疗细菌感染

Xinyu Lu¹, Yuxuan He², Jipeng Xiao³

¹College of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China; Precision Medicine Translational Research Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Journal of colloid and interface science

|September 22, 2024

概括

化微粒提供氧气来对抗细菌缺氧,增强光动力疗法 (PDT) 的有效性. 这种新的方法改善了生物膜透和抗菌活性,改善了治疗结果.

科学领域:

生物医学工程生物医学工程
摄影化学的使用.
抗菌研究抗菌研究

背景情况:

光动力疗法 (PDT) 使用光敏剂 (PS) 和活性氧物种 (ROS) 来对抗细菌感染,包括多药耐药菌株.
在感染部位和生物膜中常见的低氧环境,通过减少ROS生成,显著限制PDT的疗效.
开发克服缺氧的策略对于增强PDT的抗菌潜力至关重要.

研究的目的:

开发和评估新型化小分子 (PF-CBMs) 作为PDT中光敏感剂的载体.
研究 perfluorocarbons 在氧气输送和生物膜透中的作用,以提高 PDT 疗效.
评估化和酸诱导的表面电荷逆转对菌根稳定性,药物负载和抗菌活性的影响.

主要方法:

化 (PF-CBMs) 和无 (PC-CBMs) 微粒的合成和表征.
评估发育的小粒体的氧气承载能力和血清稳定性.
评估光敏剂加载,过早释放和细胞吸收的情况.
在体外和体内研究,以确定使用PF-CBM的PDT的抗菌膜和抗菌疗效,与PC-CBM相比.

主要成果:

由于 perfluorocarbon 含量,PF-CBMs 显示出增强的氧气运输,减轻了缺氧.
化改善了米塞尔血清稳定性,增加了光敏剂负载,并减少了过早释放.
PF-CBMs表现出酸诱导的表面电荷逆转,导致超级生物膜透.
与PF-CBMs进行PDT,与PF-CBMs相比,在体外和体内显著增强了抗菌和抗菌膜活性.

结论:

化微粒 (PF-CBMs) 通过提供氧气,有效地克服PDT中的缺氧,从而增强ROS生成.
增强氧气供应,改善稳定性和有针对性的生物膜透的结合使PF-CBMs成为先进抗菌PDT的有前途平台.
PF-CBM中的表面电荷调节进一步提高了它们在对抗细菌生物膜方面的有效性.

关键词:

抗菌的抗菌的抗菌的抗生物膜是一种抗生物膜.可充电切换的充电切换器化微粒是指化的微粒.光动力学疗法是一种光动力学疗法.

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