短延迟的 afferent 抑制及其与多发性硬化症中隐藏的感觉和手部运动损伤的关系
Wendy O Lasisi1, Katie P Wadden2, Megan C Kirkland1
1Recovery & Performance Laboratory, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
概括
在患有多发性硬化症 (MS) 的人群中,经历手动敏捷性问题时,短延迟关联抑制 (SAI) 降低. 这种SAI的减少,特别是在占优势的手中,与压力降低相关,表明感觉运动集成问题.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 康复科学 康复科学 康复科学
背景情况:
- 多发性硬化症 (MS) 由于感觉运动一体化缺陷,经常导致手工敏捷性问题.
- 皮质胆性通路在感觉运动控制中起着至关重要的作用,但它们在患有敏捷性问题的多发性硬化症中所起的作用尚不清楚.
研究的目的:
- 量化MS和手工敏捷性损伤的个体的短延迟附带抑制 (SAI).
- 为了比较MS患者和健康对照之间的SAI.
- 探索SAI,上肢功能的临床测量和MS的感官损伤之间的关系.
主要方法:
- 利用跨磁刺激 (TMS) 来评估SAI,通过将运动皮层刺激与外周中枢神经刺激在各种刺激间隔配对来评估SAI.
- 评估了22名MS患者报告手工敏捷性问题和10名年龄/性别匹配的对照人群,使用上肢临床测试,包括九洞测试和捏强度测量.
- 使用单丝试验量化感官损伤.
主要成果:
- 与对照人群相比,患有多发性硬化症的人在九孔测试中表现显著较慢,并且主导手的力减少.
- 在患有多发性硬化症的个体的主导手中观察到更大的感官损伤.
- 在MS组的优势手中发现了SAI的显著消抑制,这与的强度有负相关.
结论:
- 在患有多发性硬化症的个体中减少的SAI,特别是在主导手中,表明皮质胆固醇抑制活性受损.
- 这些发现凸显了MS中被破坏的感觉运动集成及其与功能缺陷的关联,如压力降低.
- 评估SAI可能为管理MS的感觉运动解体提供有价值的见解.
更多相关视频
07:33Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition
Published on: August 23, 2022
2.6K
14:47Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
Published on: April 21, 2023
2.6K
相关概念视频
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:25Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...