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在Sevoflurane麻醉下高频振荡和峰值速率的规范性地图集

Hiroshi Uda¹, Naoto Kuroda², Ethan Firestone³

¹Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurosurgery, Osaka Metropolitan University Graduate School of Medicine, Osaka 5458585, Japan.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

|September 22, 2024

概括

塞沃兰麻醉会增加高频振荡 (HFO) 和峰值速率,特别是在发性区域,有助于其局部化手术.

科学领域:

神经科学是一个神经科学.
发病学 (Epileptology) 是一个专业的学科.
麻醉学麻醉学

背景情况:

确定发性区域对于成功的手术至关重要.
高频振荡 (HFO) 和尖端放电是发性组织的潜在生物标志物.
麻醉剂可以影响电生理学生物标志物,使其解释复杂化.

研究的目的:

调查塞沃兰对HFO和尖端排放的剂量依赖作用.
评估这些生物标志物在区分发作发作区 (SOZ) 与非部位的有用性.
为了建立HFO的规范性数据和在不同度的Sevoflurane下峰值率.

主要方法:

分析了21名患有耐药焦点的儿童的内EEG数据.
在外科和内科记录期间使用开源检测器量化HFO和峰值率.
对SOZ和非部位之间的生物标志物率进行比较,使用不同剂量 (2-4体积%) 的Sevoflurane.

主要成果:

较高的塞沃氨酸剂量显著增加了非部位的HFO和峰值率.
生物标志物率在SOZ显著上升,相比于非部位,在2~4%体积的Sevoflurane下.
强大的效应大小 (科恩d>3.0,曼-惠特尼U测试r>0.5) 支持生物标志物差异化.

结论:

塞沃弗兰麻醉剂优先提高HFO和发性区域的峰值率.
在Sevoflurane下,HFO和峰值率的规范性地图集可以帮助定位发性区域.
评估不同部位的相对生物标志物严重程度对于手术规划是有价值的.

关键词:

准则准则准则准则内脑电图监测脑内脑电图监测儿科手术儿童手术立体电脑电图 (sEEG) 是一种脑下皮质网电皮质谱 (ECoG) 是一种电子皮质谱.

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