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Updated: Jun 12, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

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埃沃布鲁丁尼布在复发性多发性硬化症 (evolutionRMS1和evolutionRMS2) 的安全性和有效性:两个多中心,随机,双盲,主动受控,第三期试验

Xavier Montalban1, Patrick Vermersch2, Douglas L Arnold3

  • 1Department of Neurology, Centre d'Esclerosi Múltiple de Catalunya, Hospital Universitario Vall d'Hebron, Barcelona, Spain.

The Lancet. Neurology
|September 22, 2024
PubMed
概括

与teriflunomide相比,evobrutinib在复发性多发性硬化症中没有表现出更高的疗效. 安全问题,特别是肝酶升高,表明埃沃布鲁丁尼布不推用于这种情况.

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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