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在活跃的甲状腺眼病治疗反应的预测因素
Nina R Alkmim1, Kamilla M A B Rajão1, Ana R P Figueiredo2
1Serviço de Endocrinologia, Departamento de Clínica Médica da Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Av Professor Alfredo Balena 190, Belo Horizonte, MG, Brazil.
Annales d'endocrinologie
|September 22, 2024
概括
脉冲疗法有效地治疗了大多数患有活性甲状腺眼病 (TED) 的患者. 放射性治疗 (RAI) 的时间影响了反应,这表明与脉冲治疗同时使用是安全的.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
背景情况:
- 活跃的中度至重度甲状腺眼病 (TED) 是一个重大的治疗挑战.
- 静脉注射葡萄皮质激素脉冲疗法是标准的,但产生不同的反应.
- 放射性治疗 (RAI) 被认为是TED发病或恶化的危险因素.
研究的目的:
- 在活跃的TED患者中确定成功响应静脉注射甲基普雷迪尼索隆脉冲治疗的预测因素.
- 评估放射性治疗 (RAI) 与脉冲疗法的同时使用的安全性和有效性.
主要方法:
- 对64名中度至重度TED活性患者进行了回顾性分析,这些患者接受了静脉注射甲基prednisolone治疗.
- 根据临床活动得分 (CAS) 将患者分类为响应者或不响应者.
- 临床特征和结果的比较,包括RAI治疗的时间.
主要成果:
- 脉冲疗法在大多数患者 (73.4%的响应者) 中是有效的.
- 根据性别,年龄,甲状腺功能,抗体,疾病持续时间或吸烟状况,反应没有显著差异.
- 当RAI在脉冲治疗期间被给予时,相比于之后,响应率更高,并且与没有RAI治疗相似.
结论:
- 静脉注射甲基普雷迪尼索隆脉冲治疗对大多数活跃TED患者是有效的.
- RAI的时间是影响治疗反应的关键因素.
- 在脉冲治疗期间同时服用RAI似乎是安全的,并且可能有益.
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