帕克利塔塞尔在缺乏血栓形成素受体 (Mpl) 的情况下改善了血栓形成

Panpan Meng1, Wenyu Liu2, Jiawen Lao2

  • 1The Innovation Centre of Ministry of Education for Development and Diseases, School of Medicine, South China University of Technology, Guangzhou, China; Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

概括

帕克利塔塞尔通过绕过血栓形成素受体 (MPL) 途径扩大血栓细胞,可能通过JAK2-ERK1/2信号传递. 这一发现表明,帕克利塔塞尔可能有助于保护血小板并治疗相关疾病.