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评估儿童脑瘤幸存者的学术成绩与健康对照组相比
Raymond B Mailhot Vega1, Daniel J Indelicato1, Julie A Bradley1
1Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida.
International journal of radiation oncology, biology, physics
|September 22, 2024
概括
接受放射治疗 (RT) 的儿童脑瘤幸存者在学业表现明显差,包括更多的住宿和较低的数学成绩. 这突显了RT对学术成果的影响.
科学领域:
- 儿科瘤学 儿科瘤学
- 神经瘤学神经瘤学
- 教育心理学教育心理学
背景情况:
- 儿科大脑瘤的放射治疗 (RT) 可以导致认知缺陷.
- 传统的神经心理测试缺乏基线数据,可能不会促使干预.
- 学术表现提供了一个以患者为中心的结果衡量标准.
研究的目的:
- 调查小儿脑瘤幸存者 (PBTS) 接受RT治疗的学术表现作为一种新的结果.
- 将临床数据与国家收集的教育记录联系起来.
- 建立一个以患者为中心的结果测量方法,以补充现有测试.
主要方法:
- 佛罗里达州儿童学业成绩的回顾性分析.
- 50个接受RT治疗的PBTS (2007-2020年) 与150个匹配的对照进行了比较.
- 用于分析教育记录和临床数据的通用线性混合效应模型.
主要成果:
- 在RT后的PBTS获得住宿的几率是21倍 (P = .006).
- PBTS显示了两倍的等级保留率 (P = .010).
- 与对照组相比,PBTS的数学考试通过率降低了42% (P = .068).
结论:
- 这项研究是美国首次将PBTS的个人学术和临床数据联系起来.
- 学业表现是一个有意义的以患者为中心的结果.
- 教育数据补充了评估RT影响的传统神经心理测试.
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