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miR-351-5p调节CPEB3,影响SD老鼠的诱导的学习和记忆障碍
Jingjing Ji1, Yirong Xu1, Yanni Wang2
1Shanxi Medical University Fenyang College, China; Pathology Department, Shanxi Fenyang Hospital, China.
Environmental pollution (Barking, Essex : 1987)
|September 22, 2024
概括
暴露会通过增加miR-351-5p来损害学习和记忆,该miR-351-5p的目标是CPEB3. 在老鼠中抑制miR-351-5p恢复了记忆和突触功能,这表明神经毒性的治疗标.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 毒理学 毒理学 毒理学
背景情况:
- 暴露与认知缺陷有关,但分子机制尚不清楚.
- 微RNAs (miRNAs) 在突触可塑性和神经元功能中发挥作用.
- 细胞质多基化元素结合蛋白3 (CPEB3) 对于突触可塑性至关重要.
研究的目的:
- 调查miR-351-5p在引起的神经毒性的作用.
- 为了确定miR-351-5p是否调节CPEB3mRNA.
- 在认知障碍中探索miR-351-5P/CPEB3/PRPs途径.
主要方法:
- 在Sprague Dawley大鼠中的亚慢性暴露模型.
- 用于操纵miR-351-5p的腺相关病毒 (AAV) 的立体毒性微注射.
- 莫里斯水迷宫用于行为评估.
- 西方涂抹,电子显微镜和戈尔吉染色用于分子和形态分析.
- 双 luciferase 记者测定以确认目标相互作用.
主要成果:
- 暴露会影响空间学习和记忆,减少CPEB3和PRP,并增加miR-351-5p水平.
- 过度表达miR-351-5p加剧了认知缺陷,而抑制改善了记忆,并恢复了CPEB3/PRPs.
- miR-351-5p直接准CPEB3mRNA. 这是一个很好的方法.
- 诱导了突触和线粒体损伤,减少了树突棘,这些因miR-351-5p抑制而得到改善.
结论:
- 这种miR-351-5P/CPEB3/PRPs通路与的神经毒性有关.
- 抑制miR-351-5p可以缓解造成的学习和记忆障碍.
- 向miR-351-5p为引起的认知功能障碍提供了一个潜在的治疗策略.
关键词:
合金 合金 合金CPEB3 CPEB3 CPEB3 CPEB3 CPEB3 CPEB3 CPEB3 CPEB3 CPEB3 CPEB3 CPEB3在海马体内,海马体神经毒性 神经毒性SD老鼠 SD老鼠是什么意思微RNA-351-5p是一个小组.更多相关视频
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相关概念视频
MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...