在糖尿病患者中,酸盐暴露与全因死亡率之间的关联:一项前性研究
Xu Cheng1, Shiyang Zhang1, Jun An1
1Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Environmental pollution (Barking, Essex : 1987)
|September 22, 2024
概括
甲酸盐暴露与男性糖尿病患者全因死亡率的增加有关. 潜在的机制涉及荷尔蒙和IL-6通路,突出性别特异性风险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 酸盐是常见的环境污染物,与各种健康问题有关.
- 糖尿病是一种日益严重的全球健康问题,与死亡率的增加有关.
- 了解环境暴露对糖尿病患者群体的影响对于公共卫生至关重要.
研究的目的:
- 研究糖尿病患者中甲酸盐暴露与全因死亡率之间的关联.
- 探索潜在的分子机制,包括激素途径和基因相互作用,是这种关联的基础.
- 为了确定这种关联是否在男性和女性之间有所不同.
主要方法:
- 一项纵向研究从2008年至2018年跟踪了2806例糖尿病病例.
- 测量了六种甲酸盐 (PAE) 的血清水平.
- 考克斯模型和遗传分析 (多基因分数,SNP) 用于评估关联和环境-基因相互作用.
主要成果:
- 甲酸盐暴露与男性糖尿病患者全因死亡率的增加有关,但女性并非如此.
- 特定的酸盐 (DMP,DiBP,DnBP,DEHP) 在男性中显示出显著的关联.
- 丰富分析表明,与PAE相关的基因参与激素和IL-6通路,这些也受到遗传变异的修改.
结论:
- 甲酸盐暴露是糖尿病男性全因死亡的危险因素.
- 荷尔蒙系统和与IL-6相关的途径是调解这些效应的潜在分子机制.
- 性别特异性影响强调了在糖尿病人群中需要量身定制的风险评估和预防策略.
相关概念视频
Diabetes: Symptoms, Diagnosis, and Complications
516
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
516
Pathophysiology of Diabetes
900
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
900
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Psychoneuroimmunology: Diabetes and Cancer
25
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
25
Carbohydrate Metabolism
10.9K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.9K
Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K


