制药性奇托桑水凝:对其设计和应用的审查
Melbha Starlin Chellathurai1, Lip Yong Chung2, Ayah R Hilles3
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
International journal of biological macromolecules
|September 22, 2024
概括
酸盐水凝 (CS HGs) 提供可持续的,生物相容的药物输送平台. 它们的独特特性使得可控释放的治疗药物,如蛋白质和疫苗,用于先进的制药应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 制药技术 制药技术 制药技术
背景情况:
- 酸盐 (CS) 是一种可生物降解,生物相容和可持续的聚合物,在制药行业进行了广泛的研究.
- 酸盐水凝 (CS HGs) 具有粘性弹性,灵活性,柔软性和极地表面,可降低与体液的界面张力.
- CS HGs与生物组织和液体具有很好的兼容性,使其成为提供各种治疗剂的理想选择.
研究的目的:
- 全面审查CS HG的新型制备方法.
- 探索影响CS HG药物输送系统设计的参数.
- 为利用CS HG在药物输送中提供理由,并展示其多样化的制药应用.
主要方法:
- 对新型CS HG制备技术的文献综述.
- 分析影响药物释放机制的因素 (基于胀的扩散,生物侵蚀,刺激反应).
- 检查CS HG在药物输送中的作用 (延长释放,向输送,保护,粘膜粘合).
主要成果:
- 通过基于胀的扩散,生物侵蚀和刺激响应机制,CS HGs提供了多功能药物输送.
- 这些水凝通过延长释放来增强药物输送,使目标输送成为可能,保护有效载荷,并改善粘膜粘合.
- 概述了CS HG的各种新的制备方法和设计参数.
结论:
- 奇托桑水凝代表了一种多功能和先进的平台,用于制药药物输送.
- 它们的独特性质和调节性特征支持广泛的治疗应用.
- 本综述有助于更深入地了解现代药物输送系统中的CS HG.
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