身体构成,萨尔科佩尼亚和血清肌在巨症:一个叙事审查
Arthur Costa Inojosa1,2, Ana Vitória Hirt Ribeiro1,2, Thaís Florêncio Araújo1,2
1Division of Endocrinology, Agamenon Magalhães Hospital, University of Pernambuco Medical School, Recife, Brazil.
Journal of bone metabolism
|September 22, 2024
概括
患有活跃壮症的患者表现出改变的身体组成和受损的肌肉功能,包括肉类. 潜在的原因包括代谢失调,氧化应激和肌肉中的宫外脂肪,影响身体表现.
科学领域:
- 内分泌学 在内分泌学.
- 肌肉生理学 肌肉生理学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 巨症的特点是过多的生长激素 (GH) 和类似胰岛素的生长因子1 (IGF-1).
- 壮症患者经常表现出身体成分的改变,包括增加瘦肉质量和减少脂肪质量.
- 之前的研究表明,在壮症中可能存在肌肉功能障碍,但潜在的机制需要进一步阐明.
研究的目的:
- 调查活跃壮症对身体组成和肌肉功能的影响.
- 探索壮病患者肌肉功能障碍的潜在促成因素.
主要方法:
- 在壮病患者和健康对照人群之间对身体成分 (瘦身量,脂肪量,细胞外水) 的比较分析.
- 评估肌肉功能和体力表现在壮病患者.
- 对潜在的分子和代谢途径的审查,这些途径与肌肉功能障碍有关.
主要成果:
- 患有活跃壮症的患者表现出较高的瘦体质百分比和较低的脂肪体质百分比.
- 在壮病患者中观察到细胞外水区的扩张.
- 肌肉功能受到损害,有证据表明一些患者的身体表现恶化和肉症.
结论:
- 活性壮症显著改变身体组成,并对肌肉功能产生负面影响.
- 诸如肌变化,胰岛素耐药性,蛋白质代谢失调,氧化应激,神经肌肉连接障碍和宫外肌内脂肪沉积等因素可能会导致肌肉功能障碍.
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