硬化性口腔癌:升级和陷
Arushi Tomar1, Sharon John2, Shalini Gupta3
1Junior Resident, Department of oral pathology and microbiology, King George Medical University, Lucknow, India.
Seminars in diagnostic pathology
|September 22, 2024
概括
硬化性耳鼻瘤 (SOC) 是一种罕见的耳鼻瘤. 本次审查审查了其特征,诊断标准和标记,以确定是否有必要将其归类为独特的恶性病变.
科学领域:
- 口腔病理学 口腔病理学
- 在瘤学瘤学.
- 牙造成的新生病.
背景情况:
- 硬化性耳鼻瘤 (SOC) 是一种最近发现的耳鼻瘤,于2008年首次描述.
- SOC的特点是平淡的细胞学,硬化性肌瘤和积极的局部透,由于其与其他口腔病变的重叠特征,SOC存在诊断挑战.
- 报告的病例有限,并很少被列入世卫组织的分类,导致有关其病变和临床表现的文献不足.
研究的目的:
- 整合和审查关于硬化牙癌的现有文献.
- 分析与SOC相关的诊断标准和已知的分子标记.
- 评估目前支持SOC被归类为一种独特的恶性牙瘤的证据.
主要方法:
- 对病例报告和关于硬化口腔癌的评论进行了全面的文献搜索.
- 对组织病理特征,临床表现和免疫组织化学发现的分析.
- 对其在世卫组织"牙发作性囊和瘤指南"中的分类状况的审查.
主要成果:
- SOC表现出硬化层和平淡的细胞学,但表现出积极的局部透.
- 诊断的挑战来自重叠的特征与其他odontogenic和非odontogenic病变.
- 关于其一致的临床表现和发病因子的数据有限.
结论:
- 需要进一步的研究来澄清病原体,并为SOC建立一致的诊断标准.
- 该审查旨在深入了解SOC是否应该被视为一个单独的恶性口腔瘤类别.
- 澄清SOC的状态对于准确的诊断和患者管理至关重要.
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
02:30Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:24Cellular Adaptation IV: Dysplasia and Metaplasia
DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...