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高密度脂蛋白胆固醇的变化与心血管疾病风险之间的关联

Ya Wang¹, Tao Yan¹, Yuxin Yang¹

¹School of Public Health, Inner Mongolia Medical University, Hohhot, China.

Journal of clinical lipidology

|September 22, 2024

概括

高密度脂蛋白胆固醇 (HDL-C) 的变化会影响心血管疾病 (CVD) 的风险. 保持低的HDL-C或降至低水平会增加心血管疾病风险,而将HDL-C从低水平提高到高水平则会降低风险.

科学领域:

心脏病学心脏病学
生物化学生物化学
预防医学预防医学

背景情况:

心血管疾病 (CVD) 仍然是全球主要的死亡原因.
高密度脂蛋白胆固醇 (HDL-C) 在逆胆固醇运输和心血管健康方面发挥着至关重要的作用.
了解HDL-C水平的动态变化及其与发生心血管疾病的关联对于风险分层和预防策略至关重要.

研究的目的:

研究高密度脂蛋白胆固醇 (HDL-C) 度的纵向变化与发生心血管疾病 (CVD) 的风险之间的关联.

主要方法:

从2015年到2021年,对24123名参与者的队列进行了跟踪.
时间依赖的考克斯回归模型被用来分析HDL-C水平变化和CVD事件之间的关系.
HDL-C水平被分为低 (<40毫克/分升),正常 (40-80毫克/分升) 和高 (>80毫克/分升).

主要成果:

与正常水平相比,HDL-C水平降至低水平或保持低水平的参与者患心血管疾病的风险明显更高 (HR,1.24;P < 0.001).
从高水平降低到正常水平的HDL-C与心血管疾病风险略有增加有关 (HR,0.81;P = 0.039).
参与者体验到HDL-C从低水平增加到正常或高水平,表明心血管疾病风险降低 (HR,0.80;P = 0.029).

结论:

保持较低的HDL-C水平或经历到较低水平的下降与心血管疾病的风险增加有关.
相反,如果HDL-C水平从低水平提高到正常或高水平,就会降低心血管疾病的风险.
这些发现强调了监测HDL-C动态对于心血管风险评估的重要性.

关键词:

心血管疾病是什么心血管疾病群组研究是一项群组研究.高密度脂蛋白胆固醇改变了胆固醇的变化.时间依赖的考克斯回归模型

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