[基于范围审查的药物流行病学研究中时间相关偏差的识别过程]
S W Deng1, H Y Zhao2, S Y Zhan3
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China Institute for Artificial Intelligence, Peking University, Beijing 100871, China Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
|September 22, 2024
概括
与时间相关的偏差在糖尿病药物流行病学研究中很常见,可能会影响结果. 这项研究开发了一种识别和减轻这些偏见的过程,提高了研究可靠性.
科学领域:
- 药理流行病学 药理流行病学
- 糖尿病研究 糖尿病研究
- 生物统计学 生物统计学
背景情况:
- 药物流行病学研究对于了解患者群体中药物安全性和有效性至关重要.
- 与时间相关的偏差可以显著扭曲观察性研究的结果,特别是在糖尿病等慢性疾病中.
- 现有的文献缺乏系统的方法来识别和解决这些偏差在糖尿病药理学和流行病学研究.
研究的目的:
- 关于研究设计和分析,对糖尿病患者进行的近期药学流行病学研究的特征.
- 开发一个全面的过程,以识别与时间相关的偏差在这个领域.
- 提高糖尿病药物安全性和有效性研究产生的证据的可靠性.
主要方法:
- 在PubMed,Embase,CNKI和Wanfang数据库 (2012-2022) 的系统文献搜索.
- 由两个审查员进行独立选和数据提取.
- 基于文献审查和偏见机制的时间相关偏见识别过程的开发.
主要成果:
- 包括281项研究;20.64%明确提到与时间相关的偏见.
- 偏差识别的关键因素包括数据源,研究设计,对照选择,冲洗/延迟期和统计方法.
- 开发了一个详细的识别过程,包括各种设计和分析元素.
结论:
- 与时间相关的偏见在糖尿病药物流行病学研究中普遍存在,并可能影响研究结果.
- 开发的识别过程为研究人员提供了一个结构化的方法来检测和避免这些偏见.
- 实施这一过程可以提高糖尿病药物流行病学证据的质量和可靠性.
相关概念视频
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
124
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
124
01:20Chronopharmacokinetics: Time-Dependent Pharmacokinetics
106
Chronopharmacokinetics studies the temporal change in drug absorption and elimination. These changes can be cyclical or non-cyclical. Cyclical changes occur over a regular interval, while non-cyclical changes occur over a longer, irregular period.
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
106
01:29Bias in Epidemiological Studies
168
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
168
01:12Analysis of Population Pharmacokinetic Data
239
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
239
01:19Pharmacovigilance
786
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
786
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
48
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
48