[在糖尿病病中进行传统中医干预的潜在途径:巨细胞两极分化]
Wen-Ru Wang1, Xin-Hui Wang1, Lei Yan1
1Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
概括
传统中医 (TCM) 可以帮助平衡M1/M2巨分化,以改善糖尿病病 (DKD). 这种方法针对慢性炎症,并为DKD治疗和机制探索提供了潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病病 (DKD) 是2型糖尿病 (T2DM) 的严重并发症,经常因慢性微炎症而恶化.
- 巨细胞在免疫反应中至关重要,分化为M1 (促炎) 和M2 (抗炎) 类型.
- 一个M1/M2不平衡加剧DKD通过增加炎症细胞因子在脏组织.
研究的目的:
- 审查传统中医药 (TCM) 在调节M1/M2巨分极的作用,用于DKD治疗.
- 探索TCM在调节巨分化方面的潜力,以了解DKD的管理和机制.
主要方法:
- 对TCM对DKD巨细胞极化影响现有证据的审查.
- 分析涉及巨细胞两极分化的途径,包括新陈代谢,炎症,纤维化和自.
- 在TCM的多目标方法与巨细胞极化调节的相关性.
主要成果:
- 大细胞两极分化是一个动态的过程,对DKD的进展和炎症至关重要.
- TCM的活性成分和配方可以通过调节M1/M2巨细胞平衡进行干预.
- 调节巨细胞两极分化是缓解炎和改善DKD功能的一种可行的策略.
结论:
- 恢复M1/M2巨细胞平衡是DKD的一个关键治疗策略.
- 通过调节巨细胞两极分化,TCM提供了一种有希望的多目标方法来管理DKD.
- 通过巨细胞极化对DKD中TCM机制的进一步研究可以支持临床应用.
相关概念视频
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:28Diabetic Nephropathy
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...