食纤维增强了肠道微生物群产生的B族维生素池,并改变了宿主免疫格局
Erica T Grant1,2, Amy Parrish1,2, Marie Boudaud1
1Department of Infection and Immunity, Luxembourg Institute of Health, 4354, Esch-Sur-Alzette, Luxembourg.
Microbiome
|September 22, 2024
概括
食纤维通过影响维生素B的可用性来影响肠道免疫力. 特定的纤维可以恢复维生素B的水平,并支持动物模型中的免疫平衡.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 食纤维调节微生物输出,影响免疫功能.
- 除了短链脂肪酸之外,各种纤维来源对免疫力的影响尚不清楚.
- 这项研究调查了不同纤维饮食对宿主免疫力的影响.
研究的目的:
- 为了确定不同的食纤维如何影响宿主免疫反应.
- 探索纤维,肠道微生物群和B族维生素代谢之间的关系.
- 通过纤维补充来确定免疫调节的潜在策略.
主要方法:
- 使用了无特定病原体,有 gnotobiotic 和无细菌的小鼠.
- 给动物提供五种不同的食,它们的纤维含量和来源各不相同.
- 采用了大规模的 cecal 内容的代谢学和 metatranscriptomic 分析.
- 对宿主免疫群体进行了广泛的免疫类型鉴定.
主要成果:
- 缺乏纤维减少了微生物群产生的B族维生素,部分原因是微生物消费增加.
- 肠道效应性免疫细胞和激活的T细胞以微生物群依赖的方式积累.
- 胰岛素补充恢复了B族维生素的可用性和免疫常态稳定.
结论:
- 定义的纤维多糖类可以增强微生物群衍生的B族维生素的可用性.
- 食纤维可以用来调节宿主天生的和适应性免疫群体.
- 研究结果表明,食纤维,肠道微生物代谢和免疫调节之间存在联系.
相关概念视频
Bacterial Flora of the Large Intestine
397
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
397
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
323
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
323
Defense Mechanism Against Infection
6.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.5K
Anatomy of the Intestines
71.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.6K
Factors Affecting the Risk of Infection
11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K
What is Monogastric Digestion?
70.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.9K


