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SQuID (糖尿病酸性糖尿病中的皮下胰岛素) II:临床和操作有效性
Richard T Griffey1, Ryan M Schneider1, Margo Girardi2
1Department of Emergency Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
概括
该SQuID协议安全有效地治疗低至中度严重的糖尿病酸性症 (DKA),减少住院时间和重症监护室 (ICU) 的入院. 与传统的IV胰岛素相比,这种皮下胰岛素在DKA (SQuID) 方法提供了临床和操作上的好处.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病酸性酸症 (DKA) 是糖尿病的一种严重并发症.
- 此前,SQuID (DKA中的皮下胰岛素) 协议在观察环境中被证明对低至中度严重的DKA (LTM DKA) 是安全的.
- 之前的研究表明,使用SQuID协议,急诊室停留时间 (EDLOS) 减少.
研究的目的:
- 扩大SQuID协议的资格范围,以覆盖更生病的患者和普通医疗楼层.
- 以近乎实时的方式收集更详细的临床数据.
- 为了比较SQuID协议与标准静脉注射 (IV) 胰岛素治疗LTM DKA.
主要方法:
- 一个前性,观察性队列研究在一年内进行.
- 低至中度严重的DKA患者接受了IV胰岛素或SQuID协议的治疗.
- 关键指标包括治疗忠实性,安全性 (救援乳糖),有效性 (离子间隙关闭时间) 和运营效率 (EDLOS,ICU入院率).
主要成果:
- 在84名患者中,62人 (74%) 接受了SQuID治疗,22人 (26%) 接受了IV胰岛素治疗.
- SQuID患者的离子隙关闭时间较短 (1.4小时) 和协议时间较短 (10.4小时).
- 自从SQuID实施以来,LTM DKA的ICU入院率从54%降至21%以下.
结论:
- 与LTM DKA.IV胰岛素相比,SQuID协议显示出卓越的可靠性,安全性和有效性.
- 在这个机构,SQuID已成为LTM DKA的标准治疗途径.
- 该协议导致LTM DKA.的ICU入院人数大幅减少.
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