来自非短暂丝纤维素的灵活神经接口具有卓越的符合性,生物相容性和生物电导性
Zhanao Hu1, Yuqing Liang2, Suna Fan1
1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.
Advanced materials (Deerfield Beach, Fla.)
|September 23, 2024
概括
一种新的热辅助技术通过交织导电聚合物来创建强大的丝纤维蛋白神经接口. 这使得灵活,稳定和生物相容的电皮质图 (ECoG) 设备能够用于神经记录和炎症治疗.
科学领域:
- 生物材料科学 生物材料科学
- 神经科学工程 神经科学工程
- 聚合物化学 聚合物化学
背景情况:
- 丝纤维素 (SF) 为神经接口提供了卓越的生物相容性.
- 由于界面相互作用较弱,在柔性SF基板上实现导电材料的稳健整合仍然具有挑战性.
研究的目的:
- 开发一种简单的方法,在导电聚合物和丝纤维素基板之间创建持久的接口.
- 制造和评估基于丝纤维素的神经接口用于电皮质图 (ECoG) 记录和治疗应用.
主要方法:
- 采用热辅助图案传输技术,在聚3,4-乙烯二氧化 (PEDOT) 和SF之间创建一个相互透的网络.
- 该技术与喷墨打印相结合,制造出多通道神经接口.
- 神经接口的性能被评估为ECoG记录和炎症缓解的老鼠模型.
主要成果:
- 开发的技术实现了强大的,交织的接口,具有良好的灵活性 (≈33 MPa) 和高导电性 (386 S cm-1).
- 基于SF的神经接口在液体中表现出了超过4个月的良好稳定性.
- 该设备在体内研究中显示了令人满意的组织符合性,生物相容性和生物电导性.
结论:
- 热辅助图案传输技术为制造基于SF的先进灵活生物电子技术提供了有效的策略.
- 开发的基于SF的多通道神经接口是ECoG获取和治疗干预的有希望的工具,具有更广泛的生物电子应用的潜力.
相关概念视频
01:37Gap Junctions
Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
02:47The Synapse
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
01:09Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
01:28Electrical Synapses
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
01:19Ligand-gated Ion Channels
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...