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DNA甲基化年龄介导代谢特征对心血管和一般衰老的影响

Jiahui Si¹, Yu Ma², Canqing Yu^2,3,4

¹CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China (J.S.).

Circulation research

|September 23, 2024

概括

DNA甲基化钟调解了代谢物与心血管疾病和虚弱等衰老结果之间的联系. 特定的表观遗传钟在这些衰老过程中起着不同的作用.

科学领域:

表观遗传学和代谢学
衰老研究研究衰老研究
心血管疾病心血管疾病

背景情况:

脂质代谢和DNA甲基化是衰老的关键标志.
了解代谢学,表观遗传学和衰老之间的相互作用至关重要.

研究的目的:

调查DNA甲基化钟是否调解循环代谢物与发生动脉样硬化心血管疾病 (ASCVD) 和脆弱性之间的关联.

主要方法:

利用了中国Kadoorie生物银行前性队列研究.
使用Infinium甲基化EPIC BeadChip测量了DNA甲基化.
通过定量核磁共振评估代谢物概况.
使用五个表观遗传钟计算了DNA甲基化年龄加速 (AA).
确定了事件ASCVD并构建了一个脆弱指数.

主要成果:

第一代表观遗传时钟 (LiAA,HorvathAA,HannumAA) 与ASCVD风险有关.
LiAA介导的代谢物-ASCVD关联 (高达15%的LDL粒子直径).
第二代GrimAA与脆弱指数 (平均每SD增加0.10) 和风险 (33-63%) 相关.
在GrimAA中介的代谢物-脆弱性指数关联 (高达VLDL中甘油三的22%).

结论:

表观遗传学机制可能会将循环中的代谢物与衰老联系起来.
在心血管和一般衰老中,第一代和第二代DNA甲基化年龄背后有不同的机制.

关键词:

老化的老化衰老的老化心血管疾病心血管疾病脂质脂质是什么意思脂质脂质是什么意思蛋白质脂质蛋白质 (lipoprotein) 是一种蛋白质脂质蛋白质.甲基化处理的方法

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