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Updated: May 12, 2026

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
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一个拼接开关寡核酸装载的自切割DNA纳米凝

Yuwei Hu1,2, Feng Chen1,2,3, Hongfang Lu1,2,4

  • 1Institute of Materials Research and Engineering (IMRE), Agency for Science Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore. ywhu@imre.a-star.edu.sg.

Chemical communications (Cambridge, England)
|September 23, 2024
PubMed
概括

一种新型的DNA纳米凝在暴露在酸性条件下释放拼接开关寡核酸 (SSO). 这种可自切割的系统确保SSO在不变的状态下交付,为先进的治疗应用铺平了道路.

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RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...