住院炎性肠病患者的全因死亡率:伊朗的一项多中心研究
Sulmaz Ghahramani1, Babak Tamizifar2, Vahid Rajabpour1
1Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Gastroenterology and hepatology from bed to bench
|September 23, 2024
概括
传染病是住院炎性肠病 (IBD) 患者的主要死亡原因. 肺栓塞也需要在IBD护理中谨慎管理.
科学领域:
- 胃肠病学 胃肠病学
- 内部医学 内部医学
- 流行病学 流行病学
背景情况:
- 更长的寿命和像生物药物这样的先进治疗方法可能会改变炎症性肠病 (IBD) 的死亡原因.
- 了解不断变化的死亡率模式对于开发针对性IBD患者的预防和治疗策略至关重要.
研究的目的:
- 调查炎症性肠病 (IBD) 的住院患者死亡的原因.
- 确定IBD队列中主要的死亡原因和影响生存的因素.
主要方法:
- 一项多中心,横截面研究分析了从2013年到2021年住院的IBD患者的记录,其中包括1926名IBD患者.
- 关于人口统计,临床信息和死亡原因 (ICD-10分类) 的回顾性数据收集.
- 卡普兰-梅尔分析估计IBD诊断后的中位生存时间.
主要成果:
- 传染病 (32.7%),消化系统疾病 (30.1%) 和循环系统疾病 (14.2%,包括肺栓塞) 是主要的死亡原因.
- 诊断后的中位生存时间为8年;22.6%的死亡发生在入院的第一天内.
- 性结肠炎 (7.2%) 和克罗恩病 (7.8%) 的死亡率相似.
结论:
- 传染病是伊朗住院IBD患者死亡的主要原因.
- 对IBD患者的临床管理策略应优先考虑肺栓塞的预防和治疗.
- 建议进行进一步的基于人口的队列研究,以验证和扩展这些发现.
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