产前和产后大鼠暴露于银纳米颗粒的不良副作用诱导毒性
Sultan Al-Haid1, Mahmoud Elalfy1,2, Eman Alsyaed2
1Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Open veterinary journal
|September 23, 2024
概括
在怀孕期间口服接触银纳米颗粒 (AgNPs) 导致大鼠胎儿的发育问题,包括骨形和脑. 也对健康产生了不利影响,强调需要谨慎.
科学领域:
- 纳米技术 纳米技术
- 毒理学 毒理学 毒理学
- 发展生物学 发展生物学
背景情况:
- 银纳米粒子 (AgNPs) 越来越多地用于工业和医学.
- 广泛使用引发了对环境和食品污染的担忧.
研究的目的:
- 调查口服银纳米粒子给孕/哺乳老鼠及其后代的不良影响.
- 评估对发育的毒性和对孕产妇健康的影响.
主要方法:
- 在关键的怀孕日期间,孕鼠接受了不同剂量的AgNP (0,50,100毫克/公斤).
- 后代的发育和母亲的健康状况在怀孕后被评估.
主要成果:
- AgNPs在胎儿中诱导了质效应,包括延迟骨化,骨,以及大脑.
- 堤表现出死亡,卫星化和行为变化.
- 后代表现出大脑胀,但没有行为改变.
结论:
- 银纳米颗粒在50或100毫克/千克时会引起产物效应和对母体的毒性.
- 孕妇应尽量减少接触银纳米粒子.
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