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在非小细胞肺癌中基于树突细胞的免疫疗法:全面的批判性审查

Jamile Barboza de Oliveira¹, Saulo Brito Silva², Igor Lima Fernandes³

¹Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.

Frontiers in immunology

|September 23, 2024

概括

树突细胞 (DC) 免疫疗法为增强非小细胞肺癌 (NSCLC) 的抗瘤免疫提供了一种有前途的方法. 对DC子集及其组合疗法的进一步研究对于改善患者的治疗结果至关重要.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

非小细胞肺癌 (NSCLC) 的预后仍然很差,尽管免疫疗法取得了进展.
树突细胞 (DCs) 对于启动和调节免疫反应至关重要.
了解DC子集 (cDC1,cDC2,pDCs) 是调节T细胞激活和抗瘤免疫力的关键.

研究的目的:

审查基于树突细胞的NSCLC免疫疗法的不断发展的景观.
突出各种DC子集在塑造抗瘤免疫反应中的作用.
更新临床试验结果并指导未来的研究方向.

主要方法:

对过去20年的研究进行了全面的文献综述.
分析不同树突细胞子集在NSCLC免疫力中的作用.
对基于DC的免疫疗法进行临床试验数据的检查.

主要成果:

树突细胞通过影响T细胞概况 (Th1,Th2,Th17) 和调节性T细胞 (Treg) 来协调免疫反应.
内成熟的DC密度会影响瘤特异性免疫力和治疗结果.
基于直流的免疫疗法显示出克服NSCLC免疫抵抗的潜力.

结论:

树突细胞免疫疗法是NSCLC治疗的一个有前途的策略.
需要对DC子集 in situ进行进一步的表征,并将其与DC疫苗等疗法结合起来.
优化基于直流的策略可能会改善NSCLC患者的长期临床益处.

关键词:

癌症疫苗疫苗癌症疫苗检查点抑制剂检查点抑制剂树突细胞是一种树突细胞.免疫系统免疫系统免疫疗法免疫疗法肺癌是一种肺癌.瘤微环境是一个微环境.

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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.