减少心率变化与艾滋病毒感染者的临床实验室概况变化有关
Yunqiu Zhang1, Lei Han2, Luqian Shi1
1Department of Epidemiology, School of Public Health, And Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Brain, behavior, & immunity - health
|September 23, 2024
概括
艾滋病毒感染者 (PLWH) 显示心率变异性 (HRV) 降低,这表明副交感活动受损. 在低HRV的PLWH中,明显的临床特征表明与炎症和糖尿病有关.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 身体生理学 身体生理学
背景情况:
- 艾滋病毒感染与心血管并发症有关.
- 心率变化 (HRV) 反映了自主神经系统的功能.
- 了解艾滋病毒感染者 (PLWH) 的HRV对于评估心血管风险至关重要.
研究的目的:
- 为了比较PLWH和HIV阴性个体之间的HRV指数.
- 确定艾滋病毒和减少HRV之间的独立关联.
- 确定与PLWH中HRV降低相关的临床实验室概况.
主要方法:
- 对304名PLWH和147名HIV阴性个体进行了横截面分析.
- 32个常规临床实验室指数的提取.
- 将HRV指数分类为低 (Q1) 和中等至高 (Q2-Q4) 组.
主要成果:
- PLWH显示时间和频率域HRV指数显著降低 (SDNN,RMSSD,PNN50,HF,LF,VLF).
- 在调整混因子后,这些减少仍然存在.
- 低HRV的PLWH显示葡萄糖,白细胞,中性粒细胞升高,白蛋白,红细胞和CD4计数减少.
结论:
- PLWH表现出受损的副交感活动,以减少HRV为证据.
- 在PLWH中降低HRV与与炎症和糖尿病相关的不同的临床特征有关.
- 评估HRV可能有助于识别PLWH的全身并发症.
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