舌头状细胞癌的预后可以通过LncRNA LIPH4有效预测:一项前性研究
Hailei He1, Zhen Wang2, Cuilin Fang3
1Department of Oral and Maxillofacial Surgery, Ganzhou People's Hospital, Ganzhou, Jiangxi, 341000, People's Republic of China.
International journal of general medicine
|September 23, 2024
概括
在舌头状细胞癌 (TSCC) 中升高的LIPH4表达与更差的预后相关. 在TSCC中,LIPH4作为预测疾病进展和患者存活率的潜在生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 长非编码RNAs (lncRNAs) 越来越多地被认为是它们在癌症中的作用.
- 在各种恶性瘤中,LIPH4被认为是一种致癌性lncRNA.
研究的目的:
- 为了研究LIPH4在舌头状细胞癌 (TSCC) 的表达.
- 评估LIPH4在TSCC患者的预后价值.
主要方法:
- 定量逆转录聚合酶链反应 (qRT-PCR) 用于LIPH4表达分析.
- 包括千平方,卡普兰-梅尔和考克斯比例危险模型在内的统计分析.
- 评估血清LIPH4作为一个诊断指数.
主要成果:
- 与正常组织相比,TSCC组织中的LIPH4表达显著上调.
- 增加的LIPH4水平与晚期瘤分化和阶段相关.
- 过度表达LIPH4与减少无病存活 (DFS) 和整体存活 (OS) 相关.
- 血清LIPH4显示出一个有前途的诊断准确性 (AUC=0.8920).
结论:
- 在TSCC中,LIPH4是潜在的致癌因子.
- LIPH4表达是预测TSCC患者结果的重要预后生物标志物.
- 血清LIPH4可以作为TSCC的有价值的诊断和预后生物指数.
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