腹膜间皮瘤的生存预测:基于SEER数据和中国队列的nomogram
Yuting Fang1, Midan Xiang1, Zhichao Jiang1
1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Frontiers in endocrinology
|September 23, 2024
概括
这项研究开发了一种名谱,用于预测腹膜间皮瘤 (PeM) 患者的整体存活率 (OS). 诺米图有效地识别高风险个体,有助于对腹膜间皮瘤的治疗决策.
科学领域:
- 在瘤学瘤学.
- 医学统计 医学统计
背景情况:
- 腹膜间皮瘤 (PeM) 是一种罕见的恶性瘤.
- 准确的预后工具对于引导PeM患者的治疗决策至关重要.
研究的目的:
- 开发和验证用于预测腹膜间皮瘤 (PeM) 患者的整体存活期 (OS) 的名图.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 数据库和中国机构的数据.
- 使用多变量考克斯回归分析构建了一个名图.
- 使用内部和外部队列验证了名图,通过C指数,校准图和ROC曲线评估预测准确性.
主要成果:
- 纳米图包括年龄,性别,组织学类型,T阶段,M阶段和手术状态.
- 实现了强大的预测能力,C指数值从0.646到0.669不等.
- 确定性别,年龄,手术干预和M阶段作为独立的预后因素,男性性别,年龄较大和未指定的M阶段与更糟糕的结果相关,而手术改善了生存率.
结论:
- 开发的诺莫图谱是预测腹膜间皮瘤患者的存活率的可靠工具.
- 通过将患者分为不同的风险类别,名图方便了明智的治疗决策.
- 确定的主要预后因素包括性别,年龄,手术干预和M阶段.
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