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Updated: Jun 12, 2025

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一个新的疏水标签导致了被编程的死亡配体1的高效降解

Jieke Gao1, Yongli Xie2, Jiantao Zhang1

  • 1Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University 688 Yingbin Road Jinhua 321004 P. R. China zhoujinming@zjnu.edu.cn.

RSC medicinal chemistry
|September 23, 2024
PubMed
概括

新的疏水性标签绑定降解剂 (HyTTDs) 准并降解PD-L1,这是一种参与瘤免疫逃避的蛋白质. 这些新型降解剂具有较低的细胞毒性,并为癌症免疫治疗提供了一个有前途的策略.

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