微RNA-29b通过诱导线粒体功能障碍,在细胞损伤和淋巴细胞疾病中起着至关重要的作用

Jiafeng Liu1,2, Yabing Xiong1,2, Hongyan Mo3

  • 1State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangdong Provincial Key Laboratory of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

概括

糖尿病病 (DKD) 患者的微RNA-29b (miR-29b) 含量升高,通过向PGC-1α,恶化细胞损伤和功能,并损害线粒体健康. miR-29b显示出作为DKD早期诊断生物标志物的潜力.

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