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Updated: Jun 12, 2025

Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers
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阻断线粒体新陈代谢的纳米辅助剂逆转了免疫抵抗的微环境,以敏感化素结合的基于帕克利塔塞尔的化疗免疫疗法

Zaigang Zhou1, Wenjuan Luo2, Chunjuan Zheng2

  • 1National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.

Acta pharmaceutica Sinica. B
|September 23, 2024
PubMed
概括

塔莫西芬 (TAM) 向PD-L1和TGF-β,以克服对素结合的帕克利塔塞尔 (PTX@Alb) 化疗的耐药性. 这种新的线粒体代谢阻断策略增强了瘤中的药物积累和免疫反应.

关键词:
胺结合的帕克利塔塞尔化疗-免疫疗法是一种化学免疫疗法.原蛋白是一种原蛋白.药物的积累 药物的积累免疫抵抗性的微环境线粒体代谢的代谢过程编程细胞死亡 - - 结合物1转化增长因子-β的转化增长因子-β.

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