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Updated: Jun 12, 2025

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy
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Published on: April 3, 2018

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SARS-CoV-2 ORF10劫持无处不在的机器揭示了潜在的独特药物向站点

Kaixiang Zhu1,2, Lili Song3, Linyue Wang1,2

  • 1NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Acta pharmaceutica Sinica. B
|September 23, 2024
PubMed
概括

在SARS-CoV-2中,ORF10蛋白通过模仿降解信号来劫持CUL2ZYG11B酶. 这种病毒策略破坏毛功能,导致COVID-19症状,并提供新的治疗点.

关键词:
晶体结构 晶体结构药物设计 药物设计在ORF10的ORF10上.这就是SARS-CoV-2病毒.库林-2环E3结合酶的作用

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