在患有甲状腺功能低下症的女性中,冠状动脉风险因素的切断值
Deepika Srivastava1, Latheef S A A2, Venkatramana P1
1Discipline of Anthropology, School of Social Sciences, Indira Gandhi National Open University, New Delhi, India.
Bioinformation
|September 23, 2024
概括
患有甲状腺功能低下症的女性有更高的心血管风险. 这项研究发现甲状腺功能低下症和健康女性之间的冠状动脉风险因子截止值相似,有助于预防心血管疾病的早期干预.
科学领域:
- 内分泌学和心血管健康
背景情况:
- 甲状腺功能低下症增加了女性心血管疾病 (CVD) 风险和死亡率.
- 甲状腺功能低下妇女冠状动脉风险因素的最佳切断值尚未得到充分确立.
- 早期识别风险因素可以预防心血管死亡率.
研究的目的:
- 确定被诊断为甲状腺功能低下症的妇女冠状动脉风险因素的特定切断值.
- 将这些值与健康女性的值进行比较,以确定潜在的差异.
- 为早期干预策略提供信息,以预防心血管疾病死亡率.
主要方法:
- 一项涉及100名患有甲状腺功能低下症的女性和100名健康对照者的比较研究.
- 测量关键冠状动脉风险因素,包括体重指数 (BMI),腰围 (WC),甘油三和低密度脂蛋白胆固醇 (LDL-C).
- 接收机操作员特征 (ROC) 曲线分析,以确定每个变量的曲线下的面积 (AUC).
主要成果:
- 与对照组相比,患有甲状腺功能低下症的女性的平均BMI,WC,甘油三和LDL-C显著更高.
- 在ROC分析中,所有评估的变量都显示AUC值大于0.6.
- 这些风险因素的诊断性能在甲状腺功能低下和健康女性之间是可比的.
结论:
- 冠状动脉风险因子概况在患有甲状腺功能低下症和没有甲状腺功能低下症的女性之间有所不同,甲状腺功能低下症组观察到的水平更高.
- 这些风险因素的确定的切断值在确定甲状腺功能低下和健康妇女的风险方面同样有效.
- 这些发现支持在患有甲状腺功能低下症的妇女中使用标准冠状动脉风险因子查,以及时预防心血管疾病.
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