在社区居住的老年人中,左心室壁压力和意外心力衰竭
Audrey White1, Debra D Dixon2,3, Vineet Agrawal2,3,4
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
JACC. Advances
|September 23, 2024
概括
增加左心室末端透气壁应力 (LVEDWS) 与老年人患心力衰竭 (HF) 的风险更高有关. 这一发现凸显了LVEDWS作为发生性心力衰竭的潜在预测因素.
科学领域:
- 心脏病学 心脏病学
- 心血管研究研究心血管研究
- 心脏衰竭研究研究
背景情况:
- 已知左心室 (LV) 壁压力升高与现有心力衰竭 (HF) 患者的不良结果相关.
- LV 壁应力与新发 (事件) HF 的发展之间的关系不太清楚.
研究的目的:
- 为了确定与LV壁压力相关的临床因素.
- 调查LV壁应力与发生HF风险之间的关联.
主要方法:
- 分析了4601名社区动脉样硬化风险 (ARIC) 研究参与者,没有流行高血压.
- 由心声学衍生的LV末缩和末腹缩壁应力 (LVESWS,LVEDWS) 计算使用心脏尺寸,血压和E/e'比率.
- 通过ICD索赔确定的事件HF,用于协会分析的Cox回归,经过多重共变量调整.
主要成果:
- 随访4.6年的中位数显示了156个高频事件.
- 在LVEDWS中每增加1个dyne/cm2显著与发生性HF的风险增加有关 (HR:1.03;95%CI:1.01-1.06).
- LVESWS没有显示出与事件HF风险的显著关联.
结论:
- 在社区居住的老年人中,较高的LVEDWS是发生HF的重要预测因素.
- 这表明LVEDWS可以作为一种有价值的生物标志物,用于识别患心力衰竭风险的个体.
相关概念视频
Pathophysiology of Heart Failure
1.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Heart Failure Drugs: β-Blockers
320
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
320
Exercise Stress Test
178
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
178


