在有或没有Korsakoff综合征的酒精使用障碍中,补偿模式和功能连接的改变
Alexandrine Morand1,2, Alice Laniepce1,3, Nicolas Cabé1,4
1Normandie Université, UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging of Neurological Disorders', Team NeuroPresage, Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France.
Brain communications
|September 23, 2024
概括
长期使用酒精会损害大脑网络,影响记忆和执行功能. 科尔萨科夫综合征特别改变了对记忆至关重要的帕佩兹电路,尽管其他大脑网络的补偿努力.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 成研究 研究成研究
背景情况:
- 酒精使用障碍 (AUD) 是一种慢性疾病,具有显著的身体,精神和社会健康后果.
- 科尔萨科夫综合征是AUD的严重并发症,其特征是严重的记忆和执行力缺陷.
- 众所周知,前脑小脑和帕佩兹回路在AUD中受到结构性的影响.
研究的目的:
- 调查慢性,过度饮酒对前脑小脑和帕佩兹回路的静止状态功能连接的影响.
- 为了识别与Korsakoff综合征相关的静止状态功能连接异常.
主要方法:
- 对46名AUD患者 (包括14名Korsakoff综合征患者) 和31名健康对照进行了神经心理评估和休息状态功能磁共振成像 (fMRI).
- 使用感兴趣的区域和图形理论方法来分析前脑小脑和帕佩兹电路中的功能连接.
- 分析检查了功能连接性改变与神经心理表现之间的关联.
主要成果:
- 与对照组相比,AUD患者在前脑小脑电路中的总效率较低.
- 在两个电路的某些区域观察到超连接性,与执行功能有积极的相关性.
- 与没有Korsakoff综合征的AUD患者相比,患有Korsakoff综合征的患者在Papez电路内的静止状态功能连接和效率降低.
结论:
- AUD显著改变了前脑小脑和Papez电路的功能连接.
- 帕佩兹电路试图补偿AUD中的前脑小脑缺陷,但这种补偿不足,导致认知障碍.
- 帕佩兹电路内的功能连接的改变是科尔萨科夫综合征的关键特征,直接影响记忆功能.
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